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News: No-frills coats set a trend for designer viruses
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Dutch scientists have built a simple model of viruses’ protective coats in an attempt to create viral mimics that could fight diseases, as opposed to causing them. Rather than copying natural proteins, Renko de Vries from Wageningen University and his team designed and built a three-part protein from scratch that self-assembles around DNA.
‘The protein is exceedingly simple in its primary and secondary structure, yet captures the essence of self-assembly for the tobacco mosaic virus,’ de Vries tells Chemistry World. This knowledge could enable superior vehicles for getting DNA and RNA into cells, for example for gene therapy, and templates for improved DNA machines. ‘You could probably do the same with supramolecular chemistry,’ de Vries adds, ‘but the protein approach has the beauty that you can expand in the direction of synthetic biology.’
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News: Retooling for Human Gene Therapy: New and Improved Adenoviral Vectors
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Dr Juliana Small of the University of Pennsylvania, Drs Raj Kurupati, Xianqyang Zhou and their colleagues from the Wistar Institute have developed a novel adenoviral vector for delivery of multiple transgenes.
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Conferences
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17 – 20 September 2014, Summer school: Power of Viral Vectors in Gene Therapy, Primošten, Croatia |
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25 – 27 September 2014, 14th Annual Meeting of the International Society for Cell & Gene Therapy of Cancer, Amsterdam, The Netherlands |
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23 – 26 October 2014, XXII Congress of the European Society of Gene and Cell Therapy (ESGCT), The Hague, The Netherlands |
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27 – 29 October 2014, 3rd International Conference and Exhibition on Cell & Gene Therapy, Las Vegas, NV |
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17 – 20 September 2014, Summer school: Power of Viral Vectors in Gene Therapy, Primošten, Croatia |
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29 April – 1 May 2015, 9th Australasian Gene Therapy Society Meeting (AGTS), Melbourne, Australia |
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13 - 16 May 2015, American Society of Gene and Cell Therapy (ASGCT) 18th Annual Meeting, New Orleans, Louisiana |
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9 - 11 June 2015, Annual conference of the British Society for Gene Therapy (BSGT), Glasgow, UK |
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