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Newsletter September 2016

News: Novartis Drops Gene Therapy Research
Healthcare company Novartis has either fired or reassigned roughly 400 researchers previously tasked with developing cell and gene therapies. While most of those scientists will be employed by the company elsewhere, 120 positions will be eliminated, according to Reuters. The Cell and Gene Therapies Unit, led by Usman Azam, attracted attention for a promising experimental therapy based on chimeric antigen receptor T-cells (CAR-T), called CTL109, designed to treat lymphomas in children, reports BusinessInsider.

News: Gene Therapy 2016: The Pipeline Is Swelling
Door Has Been Opened to a Range of Novel Biological Therapies for Human Diseases. Twenty-seven years after Steven A. Rosenberg, M.D., Ph.D., at the National Cancer Institute Bethesda campus performed the first human gene transfer experiment, gene therapy is poised to take its place in the armamentarium of biologic therapies available to treat human diseases.
Some examples: the EMA-approval in November 2012 of Glybera® (Uniqure), an intramuscular recombinant adeno-associated virus (rAAV) product for treatment of lipoprotein lipase deficiency; and the recently announced Phase II trial results showing efficacy of another rAAV product for a genetic cause of blindness (LCA2)—for which a Biologics Licensing Application is anticipated in the U.S. this year.


News: Novel Gene Therapy Drug for Huntington's Disease
Data from Vybion on a novel treatment for Huntington's disease has been published in the Journal of Neurodegenerative diseases. The published study links the ability of Vybion's proprietary, novel Intrabody (INT41) blocking of cellular gene dysregulation to the delay of cognitive and motor function loss in the well-validated vR6/2 animal model. INT41 interferes with direct binding of toxic N-terminal huntingtin fragments to DNA, as well as their transport into the nucleus. The data support a direct gain of function of N-terminal huntingtin protein fragments that may lead to neuron dysfunction and brain atrophy as well as a novel therapeutic modality.

Conference: Gene Therapy Breakthroughs
Cambridge Healthtech Institute's conference on Gene Therapy Breakthroughs will bring together leading scientists, clinicians, executives and experts who can collectively disperse information about the impact of recent progress in gene therapy and the areas where it can be applied. The conference will highlight scientific breakthroughs, use of innovative technologies, novel approaches to tackle gene delivery, emerging translational challenges, and will bring together the right people to discuss expected pitfalls and existing opportunities in this field.

Date: September 19-22, 2016
Venue: Westin Boston Waterfront, Boston, MA.

View Full Agenda & Abstracts at: www.DiscoveryOnTarget.com/Gene-Therapy

Conference: 6th International Conference and Exhibition on Cell and Gene Therapy
Cell and Gene Therapy Conference is to ameliorate the knowledge, awareness, and education on cell and gene therapy leading to the discovery of genetic and cellular therapies which aid to alleviate the human disease as it is the most significant emerging technology in the eyes of Medical, Biotechnology, Pharmaceuticals and Academia. Cell and Gene Therapy Conference 2017 is an excellent opportunity for the delegates from Universities and Institutes to interact with the world class Scientists.

Cell Therapy Conferences will provide a perfect platform to all the Doctors, Researchers Business Delegates and Scientists to approach and deliver all the attendees about the latest scientific advancements on the respective sphere.

Theme: Exploring the novel research and innovations in Cell & gene therapy.

Date: March 2-3, 2017
Venue: Madrid, Spain

There is a 25% discount for Gene Therapy Net members. Valid up to September 30th. Register now!

More information on the conference website.

- 14 -16 September 2016, 22th Annual Meeting of the German Society for Gene Therapy (DG-GT e.V.), Heidelberg, Germany
- 20 -21 September 2016, Second Annual Gene Therapy Breakthroughs, Boston, MA
- 21 -22 September 2016, Phacilitate's Cell & Gene Therapy Europe, Berlin, Germany
- 23 -24 September 2016, 1st Congress of the Hellenic Society of Gene Therapy and Regenerative Medicine, Thessaloniki, Greece
- 1 - 5 October 2016, International Meeting on Replicating Oncolytic Virus Therapeutics, Vancouver, Canada
- 5 – 7 October 2016, Cell & Gene Therapy BioProcessing & Commercialization meeting, Boston, MA
- 10 – 11 October 2016, Adoptive T-Cell Therapy Summit Europe 2016, London, UK
- 18 – 21 October 2016, XXIV Congress of the European Society of Gene and Cell Therapy (ESGCT) and the International Society for Stem Cell Research, Florence, Italy
- 21 October 2016, Second European debate on Germline Gene Editing at ESGCT-ISSCR Congress, Florence, Italy
- 3 - 4 November 2016, 2nd Annual Cell & Gene Therapy Congress 2016, London, UK
- 16 – 18 November 2016, 15th Annual Gene Therapy Symposium for Heart, Lung, and Blood Diseases, Sonoma, California
- 5 - 7 December 2016, CRISPR Summit USA, Boston, MA
- 29 - 30 November 2016, Cell Therapy Manufacturing & Gene Therapy Congress, Amsterdam, the Netherlands
- 6 - 7 February 2017, 2nd Annual Genome Editing & Engineering Conference, San Diego, CA
- 2 - 3 March 2017, 6th International Conference and Exhibition on Cell and Gene Therapy, Madrid, Spain
- 6 - 8 March 2017, International Society for BioProcess Technology 7th Spring Meeting - Viral vectors and vaccines, Washington, DC
- 16 - 17 March 2017, Spring Symposium of the Netherlands Society of Gene & Cell Therapy (NVGCT), Lunteren, The Netherlands
- 29 - 30 March 2017, 19th International Conference on Cell and Gene Therapy - ICCGT 2017, Singapore
- 19 - 21 April 2017, Annual conference of the British Society for Gene and Cell Therapy (BSGCT), Cardiff, Wales, UK
- 3 - 6 May 2017,International Society for Cellular Therapy (ISCT) 23th Annual Meeting, London, UK
- 10 - 13 May 2017, American Society of Gene and Cell Therapy (ASGCT) 20th Annual Meeting, Washington, DC
- 14 - 19 May 2017, Gordon Research Conference: Virusses & Cells, Lucca, Italy
- 17 - 19 May 2017, World Advanced Therapies and Regenerative Medicine Congress 2017, London, UK
- 24 - 26 May 2017, 10th Australasian Gene Therapy Society Meeting (AGCTS), Sydney, Australia
- 27 - 28 November 2017, 19th International Conference on Cell and Gene Therapy - ICCGT 2017, Istanbul, Turkey


Gene Therapy Net is the information resource for basic and clinical research in gene therapy, and the site serves as a network in the exchange of gene therapy information and breaking news items. Visitors can keep track of the latest scientific papers, conference announcements, gene therapy jobs, regulations and guidelines. Other information websites created and maintained by the owner of Gene Therapy Net are Dengue Virus Net, Influenza Virus Net, Ebola Virus Net, Chikungunya Virus Net and Zika Virus Net.
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