New and Updated Clinical Gene Therapy Trials
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RGX-314 Gene Therapy Pharmacodynamic Study for Neovascular Age-related Macular Degeneration (nAMD)
Apr 6, 2021 | 18:00 pmConditions: Neovascular Age-related Macular Degeneration; Wet Macular Degeneration; Wet Age-related Macular DegenerationIntervention: Genetic: RGX-314Sponsor: Regenxbio Inc.Recruiting
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Phase I/II Clinical Trial Stem Cell Gene Therapy in RAG1-Deficient SCID
Mar 15, 2021 | 17:00 pmCondition: Severe Combined Immunodeficiency Due to RAG1 DeficiencyIntervention: Genetic: Gene therapySponsors: Leiden University Medical Center; ZonMw: The Netherlands Organisation for Health Research and DevelopmentRecruiting
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Study to Evaluate the Efficacy and Safety of PF-07055480 in Moderately Severe to Severe Hemophilia A Adults
Apr 30, 2020 | 18:00 pmCondition: Hemophilia AIntervention: Biological: Recombinant AAV2/6 Human Factor VIII Gene TherapySponsor: PfizerRecruiting
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TAC Chemotherapy and Pembrolizumab Plus Interleukin-12 Gene Therapy and L-NMMA in Triple Negative Breast Cancer
Sep 19, 2019 | 18:00 pmCondition: Triple Negative Breast CancerInterventions: Drug: Docetaxel; Drug: Doxorubicin; Drug: Cyclophosphamide; Drug: Pembrolizumab; Drug: IL-12 gene therapy; Drug: L-NMMASponsors: The Methodist Hospital System; Merck Sharp & Dohme Corp.Recruiting
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A Study to Evaluate the Efficacy and Safety of Factor IX Gene Therapy With PF-06838435 in Adult Males With Moderately Severe to Severe Hemophilia B
Mar 4, 2019 | 18:00 pmCondition: Hemophilia BIntervention: Biological: PF-06838435/ fidanacogene elaparvovecSponsor: PfizerRecruiting
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Gene Therapy for APOE4 Homozygote of Alzheimer's Disease
Aug 16, 2018 | 18:00 pmConditions: Alzheimer Disease; Early Onset Alzheimer DiseaseIntervention: Biological: LX1001Sponsors: Lexeo Therapeutics; Alzheimer's Drug Discovery Foundation; Weill Medical College of Cornell UniversityRecruiting
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Phase II High Risk Prostate Cancer Trial Using Gene & Androgen Deprivation Therapies, Radiotherapy, & Surgery
May 31, 2018 | 18:00 pmConditions: High-risk Prostate Cancer; Prostate CancerInterventions: Drug: HSV-Tk; Drug: Valacyclovir; Drug: Bicalutamide; Drug: Leuprolide Acetate; Radiation: Brachytherapy, External beam radiotherapy; Procedure: Radical prostatectomySponsor: The Methodist Hospital SystemRecruiting
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Phase I/II Trial of Lentiviral Gene Transfer for SCID-X1 With Low Dose Targeted Busulfan Conditioning
Oct 17, 2017 | 18:00 pmConditions: Severe Combined Immunodeficiency, X Linked; Gene TherapyIntervention: Biological: autologous CD34+ cell transduced with G2SCID vectorSponsor: David WilliamsRecruiting
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Follow-Up Evaluation for Gene-Therapy-Related Delayed Adverse Events After Participation in Pediatric Oncology Branch Clinical Trials
Dec 12, 2014 | 18:00 pmConditions: Pediatric Cancers; Hematologic Malignancies; Solid TumorsIntervention: Sponsor: National Cancer Institute (NCI)Recruiting
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Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID)
Mar 1, 2011 | 18:00 pmCondition: X-Linked Severe Combined Immune Deficiency (XSCID)Interventions: Drug: Palifermin; Drug: Busulfan; Biological: Ex vivo culture and transduction of the patient's autologous CD34+ HSC with lentivirus vector VSV-G pseudotyped CL20- 4i-EF1a-hyc-OPT vectorSponsor: National Institute of Allergy and Infectious Diseases (NIAID)Recruiting
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