
Login
New Clinical Trials
Related Links
Advertise on this site?
Advertising opportunities on Gene Therapy Net include standard size banners as well as text ads. Click here for more information about advertising.
You can also make a donation by PayPal and support the Gene Therapy Net website.
Latest Articles on Gene Therapy
Overview of latest articles and publications on gene therapy in PubMed, including Human Gene Therapy, Journal of Molecular Medicine and Journal of Gene Medicine. PubMed is a service of the US National Library of Medicine that includes over 18 million citations from MEDLINE and other life science journals.
- Lobetyolin alleviates IMQ‑induced psoriasis‑like skin inflammation by maintaining the homeostasis of the skin and inhibiting the inflammatory cytokines in dendritic cells Fri, 13 Jun 2025 06:00:00 -0400
Psoriasis, the most common inflammatory skin disease, is marked by excessive proliferation of keratinocytes and infiltration of immune cells into the epidermis. Current treatments, particularly biologics targeting the IL‑23/IL‑17 axis, demonstrate excellent efficacy, but issues of recurrence and side effects persist. Therefore, it is essential to identify safer and more effective alternatives. Lobetyolin (LBT), a key component of polyacetylenes in Codonopsis pilosula, exhibits potent antioxidant... - Impact of PD‑L1 upregulation on immune checkpoint inhibitor efficacy in triple‑negative breast cancer using a 4T1 murine model Fri, 13 Jun 2025 06:00:00 -0400
Triple‑negative breast cancer (TNBC) is a lethal subtype of breast cancer with a poor prognosis and limited existing treatment options. The immune checkpoint inhibitor, anti‑programmed death ligand 1 (PD‑L1), has recently emerged as a promising alternative in treating TNBC. PD‑L1 is critical in tumor immune evasion and is therefore a key target for cancer immunotherapy. Although anti‑PD‑L1 therapy is effective in breast cancer based on clinical trials, the relationship between PD‑L1 expression... - Melatonin Mitigates Sarcopenic Obesity via Microbiota and Short-Chain Fatty Acids: Evidence From Epidemiologic and In Vivo Studies Fri, 13 Jun 2025 06:00:00 -0400
CONCLUSIONS: MLT mitigated HFD-induced SO by regulating the gut microbiota and promoting the production of SCFAs. MLT might be a novel strategy for delaying the progression of SO. - Gallbladder Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm Consisting of Adenocarcinoma and Neuroendocrine Tumor G2 Diagnosed after Surgery for Acute Cholecystitis: A Case Report and Exome Analysis Fri, 13 Jun 2025 06:00:00 -0400
CONCLUSIONS: In this case report, the tumors shared a common genetic mutation, suggesting that MiNENs with NET components may share a common origin. Furthermore, the NEN component of MiNEN occurring in the gallbladder was associated with a TP53 mutation, despite the low frequency of TP53 mutations in normal NETs. - Challenges in lentiviral vector production: retro-transduction of producer cell lines Fri, 13 Jun 2025 06:00:00 -0400
The increasing demand for lentiviral vectors (LVs) has led to the development of several stable cell lines and production methods over the last 2 decades in order to increase titers and yields, reduce production costs and improve the safety of the vector product. However, the phenomenon of retro-transduction, which describes the transduction of LV producer cells by self-produced LVs, remains largely unaddressed in the context of LV production. Recent research has focused on various approaches to... - Platelet-rich fibrin-conditioned medium promotes osteogenesis of dental pulp stem cells through TGF-β and PDGF signaling Fri, 13 Jun 2025 06:00:00 -0400
CONCLUSIONS: PRF-CM activates TGF-β and PDGF signaling pathways, thereby promoting the osteogenic differentiation of DPSCs. Moreover, the volume of PRF-CM obtained was approximately three times greater than the blood sample volume. These findings suggest that PRF-CM could serve as an effective alternative to HAS or FBS for bone regeneration therapy using MSCs. - Endocrine Disorder: Advance in Understanding Diabetes and Obesity A Review Fri, 13 Jun 2025 06:00:00 -0400
One of which is several endocrine abnormalities, which are associated with obesity due to changing the hypothalamic-pituitary hormone axis and include growth hormone insufficiency, hypothyroidism, and Cushing disease and hypogonadism. Apart from storing energy, adipose tissue is involved in numerous other critical functions that can be catalyzed by adipocytes secretion of hormones (i.e., adiponectin) and chemicals (i.e., leptin). In addition, polycystic ovarian syndrome is due to the... - A Narrative Review on Oral Squamous Cell Carcinoma Fri, 13 Jun 2025 06:00:00 -0400
Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity, accounting for nearly 90% of all oral cancers. It remains a significant global health concern due to the high morbidity and mortality, often diagnosed at advanced stages despite advancements in diagnostic tools such as biopsy, imaging, and molecular markers. OSCC is driven by genetic and molecular alterations, including TP53 mutations, EGFR overexpression, and dysregulated signaling pathways that promote tumor... - Management Strategies for Xerostomia in Patients with Sjögren's Syndrome: A Comprehensive Review Fri, 13 Jun 2025 06:00:00 -0400
Xerostomia, commonly known as dry mouth, is a significant complication in patients with Sjögren's syndrome (SS), an autoimmune disorder primarily affecting the salivary glands. This comprehensive review discusses the various management strategies available to alleviate xerostomia symptoms, including pharmacological and non-pharmacological approaches. Pharmacological treatments, such as cholinergic agents (pilocarpine and cevimeline), have shown effectiveness in stimulating salivary secretion,... - Genetics in Dentistry: A Review of Advances and Implications Fri, 13 Jun 2025 06:00:00 -0400
Genetic factors have an appreciable role to play in oral health. This article investigates the genetic components of dental caries, periodontal disease, facial physical proportions, and other orofacial afflictions. Some of these disorders have been associated with specific genes. In genomics and molecular biology, the relationship between specific gene products and these kinds of disorders has been discovered. Genetic testing can thus be used to define people at higher risk for specific... - Personalized Medicine in Treating Rare Genetic Disorders: A Review Fri, 13 Jun 2025 06:00:00 -0400
Personalized medicine creates revolutionary treatments for rare genetic disorders through medicine that adjusts to individual genetic information. The development of next-generation sequencing and whole-genome sequencing through genomic research has made precise medical diagnoses along with personalized treatments possible. The current therapies using CRISPR-Cas9 and gene therapy methods tend to fix harmful mutations effectively. Biomarker discovery, along with precise diagnostic techniques... - Evaluating the Effectiveness of Platelet Rich Plasma Therapy in Enhancing Endometrial Receptivity for Women with Infertility: A Narrative Review Fri, 13 Jun 2025 06:00:00 -0400
Infertility is a condition that affects a significant percentage of couples globally, affecting their social and psychological well-being. It disrupts many aspects of life, influencing individuals' social and psychological experiences. The primary causes of infertility are diverse and include endogenous factors, various psychological variables, congenital or acquired disorders in females, and genetic and hormonal issues in males. In females, implantation failure is a key obstacle to successful... - Assessment and treatment of osteoporosis in a patient with a neurodevelopmental disorder caused by a RNU4-2 pathogenic variant (ReNU syndrome) Fri, 13 Jun 2025 06:00:00 -0400
A 16-yr-old male with a genetically undiagnosed neurodevelopmental disorder (NDD) was admitted to our outpatient clinic for skeletal assessment. DXA and HR-pQCT showed a severely reduced BMD and a pronounced reduction of trabecular and cortical bone mass. Lateral vertebral assessment identified multiple previously unrecognized vertebral fractures of the thoracic and lumbar spine. Laboratory tests indicated an activated bone turnover, which was confirmed by an increased number of osteoclasts and... - Female Simplex Carriers of X-Linked Retinal Dystrophies: A Case Series Fri, 13 Jun 2025 06:00:00 -0400
CONCLUSION: The absence of family history does not preclude X-linked inheritance in females with retinal dystrophies. Multimodal imaging such as FAF and red-free photos should be included in the workup. As new therapeutic strategies are developed for CHM and RPGR-associated retinal degeneration, including gene therapy, it may become increasingly more important to diagnose symptomatic carriers, as it has been previously shown that earlier intervention is more effective in IRD populations. - Increased maternal exercise of moderate intensity improves pregnancy outcomes of gestational diabetes mellitus patients through maintaining the balance of the gut microbiota Fri, 13 Jun 2025 06:00:00 -0400
CONCLUSION: There were significant differences in the composition and structure of the gut microbiota of patients with GDM with different exercise levels. - CRISPR antiviral inhibits neurotrophic JC polyomavirus in 2D and 3D culture models through dual-gRNA excision by SaCas9 Fri, 13 Jun 2025 06:00:00 -0400
Without an effective antiviral, JC virus (JCV) has persisted throughout multiple epochs of immunosuppression, causing the opportunistic demyelinating disease, progressive multifocal leukoencephalopathy (PML). This study proposes a novel therapy using a dual-gRNA, SaCas9, CRISPR antiviral targeting JCV transcription factor, large tumor antigen (LT-Ag), and capsid protein, viral protein 1 (VP1). This treatment was validated using traditional two-dimensional cell culture. A recombinant cell line... - The Tumor-Associated Neutrophils-Related Signatures Predict Prognosis and Indicate Immune Landscape in Colorectal Carcinoma Fri, 13 Jun 2025 06:00:00 -0400
Background: Tumor-associated neutrophils (TANs), a major immune cell type in the tumor microenvironment (TME), are associated with antitumor or pro-tumor phenotypes. A wealth of evidence evidences demonstrated that the content of TANs has been implicated in the pathogenesis of cancer and may be ideal targets for cancer therapy. In this study, we identified TANs-related genes to construct a prognostic model and evaluated its potential as a biomarker for predicting prognosis and immunotherapeutic... - A review of adipose-derived mesenchymal stem cells' impacts and challenges: metabolic regulation, tumor modulation, immunomodulation, regenerative medicine and genetic engineering therapies Fri, 13 Jun 2025 06:00:00 -0400
Adipose-derived mesenchymal stem cells (ADSCs), multipotent stromal cells abundant in adipose tissue, exhibit remarkable plasticity in modulating systemic metabolism, inflammatory responses, and immune homeostasis. Their bidirectional interactions with the tumor microenvironment (TME) position them as both accomplices and antagonists in cancer progression, offering unique therapeutic opportunities. ADSCs also hold significant potential for clinical application in the fields of regenerative... - Integrated multi-omics analysis and experimental investigation of mitochondrial dynamics-related genes: molecular subtypes, immune landscape, and prognostic implications in lung adenocarcinoma Fri, 13 Jun 2025 06:00:00 -0400
CONCLUSION: MD-related genes exhibit strong prognostic and immune subtyping value. The proposed risk model holds clinical potential, and MTCH2 may serve as a promising target for precision therapy in LUAD. - Chitinase-1 inhibition attenuates metabolic dysregulation and restores homeostasis in MASH animal models Fri, 13 Jun 2025 06:00:00 -0400
CONCLUSIONS: These results revealed the key role for CHIT1 in regulating metabolism. OATD-01 is a macrophage modulator that can directly restore metabolic balance and consequently inhibit inflammation and fibrosis, supporting its use for MASH treatment.
Literature Menu
- Cancer Gene Therapy
- Current Gene Therapy
- Current Molecular Medicine
- Gene Therapy
- Gene Therapy and Molecular Biology
- Gene Therapy and Regulation
- Genetic Vaccines and Therapy
- Human Gene Therapy
- Journal of Gene Medicine
- Journal of Molecular Medicine
- Molecular Therapy
- Nature Medicine
- Open Gene Therapy Journal
- Trends in Molecular Medicine
Gene Therapy News
- Gene therapy offers long-term relief for Haemophilia B: Study - Daijiworld
Fri, 13 Jun 2025 14:38:3 GMT - New Scalable Cell Lysis Method Introduced for Viral Vector Harvest in Gene Therapy Production - geneonline.com
Fri, 13 Jun 2025 14:15:3 GMT - Medera and Novoheart Presented Breakthroughs in Human mini-Heart Platforms and Gene Therapy at ISSCR 2025 - GlobeNewswire
Fri, 13 Jun 2025 14:01:3 GMT - Fractyl Reveals Single-Dose Gene Therapy Data for Diabetes Treatment at ADA 2025 | GUTS Stock News - Stock Titan
Fri, 13 Jun 2025 13:00:0 GMT - Cell And Gene Therapy Market Set to Witness Unprecedented - openPR.com
Fri, 13 Jun 2025 12:53:3 GMT